2008 Lemelson-MIT Prize for Invention
Among DeSimone’s notable inventions is an environmentally friendly manufacturing process that relies on supercritical carbon dioxide instead of water and bio-persistent surfactants (detergents) for the creation of fluoropolymers or high-performance plastics, such as TeflonÂ®. More recently, he worked on a team to design a polymer-based, fully bioabsorbable, drug-eluting stent, which helps keep a blocked blood vessel open after a balloon-angioplasty and is absorbed by the body within 18 months.
DeSimone’s newest invention is PRINTÂ® (Particle Replication in Non-wetting Templates) technology, used to manufacture nanocarriers in medicine. At present, DeSimone’s Lab is vested in a variety of projects that also extend beyond medicine, including potential applications for more efficient solar cells and morphable robots. In 2004, DeSimone co-founded Liquidia Technologies with a team of researchers from UNC to make the technology available in the market. Liquidia is using the PRINT technology to develop precisely engineered nanocarriers for highly targeted delivery of biological and small molecule therapeutics to treat cancer and other diseases. DeSimone’s proposed applications for cancer treatment with the PRINT platform was instrumental in UNC landing a grant of $24 million from the National Cancer Institute to establish the Carolina Center for Cancer Nanotechnology Excellence.
“You can do all the innovating you want in the laboratory, but if you can’t get it out of the university walls you do no one any good,” said DeSimone. He instills an entrepreneurial spirit in his students that focuses on the importance of commercializing technology and scientific inventions. One of DeSimone’s greatest accomplishments is his mentorship of more than 45 postdoctoral research associates, 52 Ph.D. candidates, six M.S. theses and 21 undergraduate researchers. Furthermore, he speaks to groups of high school students about the inventive process and encourages them to learn and explore areas that are less familiar to them to broaden their exposure to other disciplines.
A prolific inventor, DeSimone holds more than 115 issued patents with more than 70 new patent applications pending, and he has published more than 240 peer-reviewed scientific articles.